42 Results for "

Uncaria sessilifructus Roxb.

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "Uncaria sessilifructus Roxb." in MCE Product Catalog:

9
Engeletin
Engeletin
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9 Publications Verification
Cat. No.: HY-N0436
CAS No.: 572-31-6
Category:  

Plants Flavanonols Liliaceae Flavonoids Microorganisms Phenols Polyphenols Smilacis Glabrae Rhizoma Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
6
Corynoxeine
Corynoxeine
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6 Cited Publications
Cat. No.: HY-N0590
CAS No.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
4
Nitidine chloride
Nitidine chloride
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4 Cited Publications
Cat. No.: HY-N0498
CAS No.: 13063-04-2
Category:  

Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .
3
Corynoxine
Corynoxine
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3 Cited Publications
Cat. No.: HY-N0901
CAS No.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
2
Rhynchophylline
Rhynchophylline
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2 Cited Publications
Cat. No.: HY-N0387
CAS No.: 76-66-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Other Diseases Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

NF-κB

Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .
2
Hirsuteine
Hirsuteine
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2 Cited Publications
Cat. No.: HY-N2197
CAS No.: 35467-43-7
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Neurological Disease Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

nAChR

Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
1
Hirsutine
Hirsutine
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1 Cited Publications
Cat. No.: HY-N2193
CAS No.: 7729-23-9
Category:  

Infection Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

Flavivirus Dengue Virus Apoptosis

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
Phloracetophenone
Phloracetophenone
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Cat. No.: HY-W008226
CAS No.: 480-66-0
Synonyms: 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone
Category:  

Metabolic Disease Plants Curcuma comosa Roxb. Infection other families Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Zingiberaceae

Target:  

Cytochrome P450 Bacterial Antibiotic

Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .
Mitraphylline
Mitraphylline
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Cat. No.: HY-N6946
CAS No.: 509-80-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo .
Velutinam
Velutinam
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Cat. No.: HY-N16516
CAS No.: 146428-62-8
Category:  

Alkaloids Pyrrole Alkaloids Uvaria grandiflora Roxb. Plants Annonaceae

Target:  

Bacterial

Velutinam is an alkaloid. Velutinam can be isolated from twigs of Uvaria grandiflora Roxb. Velutinam shows antioxidant activity. Velutinam can be used in the research of bacterial infections .
Isopteropodine
Isopteropodine
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Cat. No.: HY-N4157
CAS No.: 5171-37-9
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants

Target:  

mAChR 5-HT Receptor Bacterial

Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .
Jaslanceoside B
Jaslanceoside B
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Cat. No.: HY-N16539
CAS No.: 188300-82-5
Category:  

Gastrodia elata Bl. Orchidaceae Plants Saccharides Monosaccharides

Target:  

Others

Jaslanceoside B is a secoiridoid glucoside found in Jasminum lanceolarium Roxb .
Esculentoside B
Esculentoside B
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Cat. No.: HY-N6032
CAS No.: 60820-94-2
Synonyms: Phytolaccoside B
Category:  

Plants Phytolaccaceae Phytolacca americana L.

Target:  

Cholinesterase (ChE) JNK NF-κB Fungal

Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity .
NMac1
NMac1
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Cat. No.: HY-115507
CAS No.: 1332290-68-2
Target:  

AMPK mTOR ERK Oxidative Phosphorylation Reactive Oxygen Species (ROS) Ras

Research Areas:  

Cancer

NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC50 of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb .
Uncarine F
Uncarine F
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Cat. No.: HY-N16467
CAS No.: 14019-66-0
Synonyms: Speciofiline
Category:  

Alkaloids Oxindole Alkaloids Rubiaceae Plants Mitragyna parvifolia (Roxb.) Korth.

Target:  

Others

Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .
Xanthorrhizol
Xanthorrhizol
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Cat. No.: HY-112657
CAS No.: 30199-26-9
Purity:  98.46%
Category:  

Plants Infection Monophenols Terpenoids Sesquiterpenes Phenols Curcuma xanthorrhiza Roxb. Curcuma longa Disease Research Fields Zingiberaceae

Target:  

Bacterial

Xanthorrhizol, isolated from Curcuma xanthorrhiza Roxb, is a potential antibacterial agent.
Uvarigranol B
Uvarigranol B
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Cat. No.: HY-N2634
CAS No.: 164204-79-9
Category:  

Natural Products Uvaria grandiflora Roxb. Other Diseases Plants Annonaceae Disease Research Fields

Target:  

Others

Uvarigranol B, a polyoxygenated cyclohexene, is obtained from the roots of Uvaria grandiflora Roxb (Annonaceae) .
4'-Hydroxy-6,7,8,3'-tetramethoxyflavonol
4'-Hydroxy-6,7,8,3'-tetramethoxyflavonol
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Cat. No.: HY-N8203
CAS No.: 1879030-01-9
Category:  

Flavonols Flavonoids Combretaceae Getonia floribunda Roxb Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Others

4'-Hydroxy-6,7,8,3'-tetramethoxyflavonol is a natural compound that could be found in Getonia floribunda Roxb .
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
0 Images
Cat. No.: HY-N1792
CAS No.: 91095-51-1
Category:  

Triterpenes Terpenoids Rubiaceae Uncaria sessilifructus Roxb. Plants

Target:  

Others

3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoids product that can be isolated from the herbs of Uncaria sessilifructus. .
Assay Types